【Purposes】The corneal shape and mechanical properties of the cornea and contact lens material have a certain impact on the correction effect of the contact lens.【Methods】In this paper, a finite element model of corneal wearing orthokeratology lens was established using hyperelasticity materials, and the biomechanical response of the cornea after wearing the lens was analyzed by changing the shape of the cornea (different curvature and thickness) and the material parameters of the cornea and the orthokeratology lens.【Findings】The results showed that when the corneal curvature changed 4 D, the difference in displacement

at the apex of the central area of the cornea changed by 15.7μm, and when the corneal thickness changed by 75μm, the difference in displacement at the apex of the central area changed by 12.3μm; when the corneal material parameterk1changed by 3 times, the change of difference in displacement at the apex of the central area of the cornea was 39.2μm, when theC10value changed by 4 times, the change of difference in displacement was 55.5μm, while when the orthokeratology lens material parameterEchanged by 3 times, the change of difference in displacement was only 0.2μm.【Conclusions】When using orthokeratology lens to correct myopia, it is necessary to fully consider the influence of corneal morphology and the mechanical properties of the cornea on the correction effect.