Introduction
Bimonthly, started in 1957
Administrator
Shanxi Provincial Education Department
Sponsor
Taiyuan University of Technology
Publisher
Ed. Office of Journal of TYUT
Editor-in-Chief
SUN Hongbin
ISSN: 1007-9432
CN: 14-1220/N
Administrator
Shanxi Provincial Education Department
Sponsor
Taiyuan University of Technology
Publisher
Ed. Office of Journal of TYUT
Editor-in-Chief
SUN Hongbin
ISSN: 1007-9432
CN: 14-1220/N
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TfOH-Catalyzed Formal[3+2]Cycloaddition of Aziridines with Nitriles
DOI:
10.16355/j.cnki.issn1007-9432tyut.2018.04.004
Received:
Accepted:
| Corresponding author | Institute | |
| LI Xing | College of Chemistry and Chemical Engineering, Taiyuan University of Technology |
abstract:
Significant medicinal value of imidazolines has raised scientists wide attention in rencent years.To explore a green universal and effective method of imidazoline synthesis, in this paper trifluoromethanesulfonic acid (50%) as a catalyst and dichloroethane as solvent were selected by single factor screening, under which various N-tosylaziridines reacted effectively and rapidly with diverse nitriles via a[3+2]cycloaddition way.The reaction can proceed smoothly to obtain various imidazolines with good to excellent yields and wide substrate scope.
Keywords:
cycloaddition; aziridine; nitrile; TfOH; imidazolines;