Based on the academic thought of non-aqueous fracturing, the coal cylindrical samples with different crack morphology were obtained by water and Sc-CO2 fracturing. The permeability of coal after fracturing was measured under in-situ conditions, thus the fracturing characteristics and anti-seepage effect of water and Sc-CO2 cracked coal is analyzed. The results show that, compared with hydraulic fracturing, under the same stress condition, Sc-CO2 fracturing has a lower initiation pressure, the curve of pump pressure-time fluctuating less, and more complicated fracture-network;The initiation and propagation direction of fracture in Sc-CO2 fracturing is affected by three-dimensional stress, weak planes such as bedding planes, and primary cracks. After Sc-CO2 and water fracturing, under the axial pressure×confining pressure of 12 MPa×10 MPa, the permeability is increased by 472 times and 34 times compared with the intact coal, respectively. While the permeability is increased by 47 times and 19 times after Sc-CO2 and water fracturing when the axial pressure×confining pressure is 16 MPa×10 MPa, respectively. Under the same stress condition, the permeability enhancement of Sc-CO2 fracturing is better than hydraulic fracturing.