To investigate the mechanical properties of 3D printing nacre composite under quasi-static compressive engineering status, the regular patterns of mechanical property developpment of 3D printing nacre composite under the influence of detail size changes were explored. Photocuring 3D printing moulding fabrication method was adopted and rigid non-transparent plastic Vero Blue was applied to hard bricks and soft rubber Tango Black was used to soft glue layers for the purpose of the fabricfation of nacre composite specimens with different aspect ratios of hard bricks and different soft glue layer thicknesses. Meanwhile, quasi-static compressive mechanical testing technique was accepted and the verification by finite element analysis software ABAQUS was combined simultaneously to investigate the compressive mechanical properties of nacre composite. Both of the experiment and the numerical analysis have shown clearly that the dominant damage pattern of 3D printing nacre composite is cracking of soft glue layers. And data results have shown that when thickness of soft glue layers is constant, the improvement in aspect ratio of hard bricks can improve compressive elastic modulus of entire material by the amplitude of 22%-48%. And from another angel, when aspect ratio of hard bricks is fixed, the decrease of soft glue layer thickness can increase crack energy of specimens by the amplitude of 190%-253%. Moreover, through the analysis of compressive stresses of specimens under a certain moment, results have shown that finite element analysis and experiment results coincide agreeably.