Thermal environment assessment of non-uniform buildings has always been a hot issue in thermal comfort research. Different from the premise of classical thermal comfort evaluation, the thermal environment of non-uniform buildings is generally accompanied by the temporal variability of various environmental parameters and the non-uniformity of spatial distribution, which determines that the evaluation method or index is quite different from the classical thermal comfort evaluation method. This paper introduces several main evaluation ideas of non-uniform building thermal environment, reveals the main consideration angle and key points of non-uniform building thermal environment, and provides a comprehensive reference for its further accurate evaluation.