In order to deal with the shoulder lateral impact damage that is prone to occur in real life, the mechanical response of the shoulder under lateral impact of 3.5 m/s was discussed, and the vulnerable parts were predicted according to the stress distribution.On the basis of the principle of reverse engineering, a finite element model of human shoulder joint including bone, ligaments, cartilage, muscle and other tissues was constructed by using commercial software.When calculation time was ensured, the number of grids was increased as much as possible to ensure the precision and accuracy of the results.The changes of displacement were given through static lateral loading.By comparing with previous experimental data, the validity of the model was verified.The results show that the static displacement of the model was basically consistent with the experimental data of corpse.The peak value of the Von Mises stress in lateral impact was 70.12 MPa.The descending order of injury probability was scapular neck, humeral head, humeral neck and subclavian surface.In the prevention and treatment of shoulder lateral collision, the damage of these positions should be considered firstly and the corresponding protection and fixing measures should be taken accordingly.