The failure of endovascular interventional therapy for lower extremity peripheral arterial disease is a key problem that needs to be solved urgently in clinic. The calcification degree of plaque is an important factor to determine the therapeutic effect. In this study, numerical simulation was used to investigate the stress state of the plaque and the artery wall during the upright and movement of the lower extremity after the stent was placed into the diseased arteries with calcified plaques(light, moderate, and heavy), and to evaluate the effect of the severity of the plaque calcification on treatment outcome. The results show that the plaque located on the lateral side of the curved artery was in fatigue state after the stent implantation during limb movement, and rupture probably occurs owing to structural failure, among which the plaque with moderate calcification had the highest peak principal stress. The maximum plastic equivalent strain of the three kinds of plaque occurred at the narrowest part of the plaque, and the heavy calcified plaque had the highest plastic strain with the lowest stenosis rate in the upright and moving state. The arteries with light and heavy calcified plaques have similar mechanical properties. Arteries with moderate calcified plaques are most susceptible to damage in the narrowest part of the plaque and the junction between the plaque and healthy arteries. This study provides a comprehensive evaluation and elaboration of the mechanism of the location of the lesion artery prone to rupture with plaque of various calcification degree from the perspective of mechanical biology, providing a guideline for choosing different treatment strategies and prognosis in clinic.