Introduction
Bimonthly, started in 1957
Administrator
Shanxi Provincial Education Department
Sponsor
Taiyuan University of Technology
Publisher
Ed. Office of Journal of TYUT
Editor-in-Chief
SUN Hongbin
ISSN: 1007-9432
CN: 14-1220/N
Administrator
Shanxi Provincial Education Department
Sponsor
Taiyuan University of Technology
Publisher
Ed. Office of Journal of TYUT
Editor-in-Chief
SUN Hongbin
ISSN: 1007-9432
CN: 14-1220/N
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Synthesis, Characterization and Antitumor Activity of Mononuclear Ruthenium (Ⅱ) Complexes
DOI:
10.16355/j.cnki.issn1007-9432tyut.2020.05.010
Received:
Accepted:
| Corresponding author | Institute | |
| ZHANG Yan | School of Chemical and Biological Engineering, Taiyuan University of Science and Technology |
abstract:
Two mononuclear ruthenium complexes were synthesized and characterized by elemental analysis, infrared spectroscopy, 1H NMR, and electrospray ionization mass spectrometry. Their photophysical and electrochemical properties were also studied. The cytotoxicity to cervical cancer(Hela), gastric cancer(BGC823), and human breast cancer(MCF-7) of the two complexes in vitro was evaluated by using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. It is worth noting that Ru1 and Ru2 showed excellent antitumour effects in a cellular study for MCF-7 in vitro. However, Ru1 exhibited higher cytotoxicity to any cancer cells than Ru2. The results reveal that Ru1 and Ru2 have obvious selectivity and might be a potential anticancer agent to improve the efficacy of common anticancer therapies. The mode of cell apoptosis was assessed by Hoechst staining and flow cytometry assay.
Keywords:
Ru(Ⅱ) complexes; spectral characteristic; electrochemistry; antitumor activity; cell apoptosis;