Cadmium ion imprinted polymers were prepared by using inverse emulsion method and used to remove Cd(Ⅱ)from aqueous solution. Response surface method of Box-Behnken design was applied with the adsorption capacity of cadmium ion imprinted polymers as the response value, adsorption time, temperature and pH as parameters. Results suggest that the values of F and R²obtained from the analysis of variance model are 15.56 and 0.952 4, respectively. It is concluded that binomial regression equation can well reflect and predict the results obtained in this experiment; Adsorption time, temperature and pH have significant impact on the adsorption capacity of cadmium ion imprinted polymers, with a decreasing sequence of adsorption time, pH, and temperature.