The shield tunnel construction disturbance effects of Taiyuan Metro Line 2 Shuangtaxi Street-Dananmen interval were studied by FLAC3D numerical simulation method. With pile length, pile diameter and pile spacing as factors, subsidence and tilt rate as indexes, orthogonal test method was used to study the effect of isolation pile on tunnel which closely passes high-rise building, and the parameters of the isolation pile were optimized. The results show that the reasonable selection of parameters is beneficial to controlling the deformation of buildings. For the building deformation, pile spacing is the first influence factor; the second one is the pile length and the third one is the pile diameter. From the comprehensive effects of deformation control and construction cost control, the obtained pile spacing is 1.2 m, pile length is 30 m, pile diameter is 800 mm.