Electrocatalytic carbon dioxide(CO2) reduction is an efficient strategy for renewable energy storage and utilization as well as relieving green house effect. The development of efficient catalysts for CO2 reduction is an effective route to suppress hydrogen evolution and improve CO2 reduction activity. Copper has been revealed as a promising candidate for CO2 reduction, however, it exhibits relatively low selectivity to carbon monoxide(CO). Cu-In-S was prepared by introducing S and In to Cu nanowires for CO2 reduction. It exhibits highly efficient performance for CO2 reduction, the current density and Faraday efficiency to carbon monoxide have been significantly improved. The introduction of S can effectively increase the roughness of the electrocatalyst and increase its electrochemical active area. The introduction of In effectively inhibits hydrogen evolution and improves the activity of CO2 reduction to carbon monoxide.